GET THE APP

Antimicrobial activity of some novel 1-(1,3,4-oxadiazol-2-yl)-1Hbenzo[d]imidazolele substituted derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Antimicrobial activity of some novel 1-(1,3,4-oxadiazol-2-yl)-1Hbenzo[d]imidazolele substituted derivatives

Author(s): Neetu Soni, Namrata Soni and Pushpraj Gupta

In this study 12 benzmidazoles bearing oxadiazole moiety were synthesized in order to investigate their possible antibacterial and anti-fungal activities. Derivatives of benzimidazole were synthesized by nucleophilic substitution of 1H benzimidazoles with ethylchloroformate to yield acetate. The resulting acetate on the treatment with hydrazine hydrate and further with substituted carboxylic acid in the presence of phosphorous oxy chloride afforded corresponding oxadiazole derivatives. The structures of all compounds were established by IR, 1HNMR, 13C NMR and mass spectral data. Almost all newly synthesized compounds showed moderate to good antimicrobial activity.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 25868

Der Pharma Chemica received 25868 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry