Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Antimicrobial activity of some novel triazole-3-thione containing substituted piperazine moiety

Author(s): Harish Rajaka*, Bhupendra S Thakura, Poonam Parmara, Pramod Kumara Arun Kumar Guptab,Navneet Agrawalc and Prabodh Chander Sharmad

A novel series of triazole analogues possessing substituted piperazine were synthesized and their structures were elucidated using elemental analysis, IR, 1H-NMR and mass spectral data. The synthesized compounds were tested for their in-vitro antimicrobial activity against the microbial strains i.e., Staphylococcus aureus, Bacillus subtilis, Proteus mirabilis, Pseudomonas aeruginosa, Aspergillus niger and Candida albicans using disk diffusion method. Some of compounds displayed noticeable biological activity against all the pathogenic microorganisms tested including Pseudomonas aeruginosa and Candida albicans responsible for nosocomial infection. Structure activity relationship among the synthesized compounds was also studied.


PDF