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Antimicrobial screening and molecular docking studies of some novel triazoloquinazolinone derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Antimicrobial screening and molecular docking studies of some novel triazoloquinazolinone derivatives

Author(s): T Elavarasan, D Bhakiarajand and M Gopalakrishnan*

Triazoloquinazolinoneand their derivatives have been studied extensively for various biological activities such as antimicrobial, anti-inflammatory, antitumor, antioxidant and anti-HIV activity. All the synthesized compounds have been screened for their antibacterial activity againstS.aureus, B.subtilis, S.typhi, E.coli, V.cholerae and K.pneumonia and antifungal activity againstA.flavus, A.niger,C.albicans, Mucor,Candida 6 and Rhizopus.Evaluation of antimicrobial activity shows that several compounds exhibits good activity when compared with the reference drug candidates and thus could be promising new lead molecules. The molecular docking studies have widened the scope of developing a new class of antimicrobial agents.


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