Antioxidant Activities of N-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)pyridin-4- amine derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Antioxidant Activities of N-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)pyridin-4- amine derivatives

Author(s): F. Abrigach, M. Khoutoul, S. Merghache, A. Oussaid, M. Lamsayah,A. Zarrouk, N. Benchat, R. Touzani

A serie of pyrazolic heterocyclic compounds processing -NH function (1-14) have been prepared in one step by condensation of one equivalent of (3, 5-dimethyl-1H-pyrazol-1-yl) methanol or (1H-pyrazol-1-yl) methanol with one equivalent of appropriate primary amines. The antioxidant activities of these compounds have been investigated with the rate ranging for the best one such as the compounds 8 (96.64% at 80 mg/mL), 1 (77.31% at 80 mg/mL), 10 (71.71% at 80 mg/mL), 3 (58.79 at 80 mg/mL) and 4 (49.57% at 80 mg/mL).


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