Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Antioxidant and antimicrobial screening of Ciprofloxacin derivative and its complexes

Author(s): Vandna Singh, Anju Nagar and Preeti Jain

The research article presents the synthesis of ciprofloxacin derivative with Benzil dihydrazone and its metal complexes with Co (II), Ni(II), Cu(II) salts. The molecular formula proposed for ligand is (C48H46F2N10O4) and for complexes [M(C48H46F2N10O4)X2] where M= Co (II), Ni(II), Cu(II) and X= Cl- . 1H NMR, IR and UV-Vis, EPR spectra were recorded to confirm the formation of ligand (Ciprofloxacin derivative) and metal complexes. The proposed geometry of complexes was octahedral which is further confirmed by electronic spectra and magnetic moment analysis. The compounds were screened for their antimicrobial, antioxidant activity using disc diffusion method and DPPH Scavenger activity method. Ni (II) complex has shown significant antibacterial activity with maximum zone of inhibition against E. coli while Co(II) and Ni(II) complexes are most effective against B.Cereus. Antimicrobial activity of the ligand has been enhanced on complexation with Ni(II) and Co(II) ions. Antioxidant activity of complexes was compared with ascorbic acid and ciprofloxacin itself and it was observed that Cu (II) complex has shown remarkable antioxidant activity at variable concentrations.


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