In the present study the ability of lycorine as an antioxidant to protect against CCl4 induced oxidative stress and hepatotoxicity in Albino mice was investigated. Oral administration of CCl4, administered twice a week, produced a marked elevation in the serum levels of aspartate transaminase, alanine transaminase, Serum glucose, urea, bilurubin, lipid peroxidation and decreases of antioxidant status such as Catalase and superoxide dismutase. However, intraperitoneal [5 mg/ kg of body weight, IP ] administration of lycorine daily for 8 weeks significantly reduced the aspartate transaminase, alanine transaminase, Serum glucose, urea, bilurubin, lipid peroxidation and increased the activities of catalase and superoxide dismutase and it was compared with silymarin. Therefore, the results of this study show that lycorine can be proposed to protect the liver against CCl4 induced oxidative damage in mice, and the hepatoprotective effect might be correlated with its antioxidant and free radical scavenger effects.
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