To develop gel using Methylsulphonylmethane powder and seed oil of Pongamia pinnata Linn to minimize side effects of current therapy. All prepared formulations were evaluated for pH, viscosity, spreadability, extrudability. The release of optimized batch was carried out using cellophane membrane into phosphate buffer 6.8 at 37°C. The characterization was carried out by using Fourier Transform Infra-Red (FTIR), Differential Scanning Calorimetry (DSC), and Scanning Electron Microscope (SEM) analysis. In vitro and in vivo activities were performed by using HaCaT cell line and Mouse tail model respectively.