GET THE APP

Antitubercular and Cheminformatic Study of Substituted Benzofuran C-2 Coupled Quinoline Carboxylate Analogous | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Antitubercular and Cheminformatic Study of Substituted Benzofuran C-2 Coupled Quinoline Carboxylate Analogous

Author(s): Satyanarayan ND, Anantacharya R, Santoshkumar S

Coupled heterocycles are becoming interesting biological targets in bringing out potent pharmaceuticals for the treatment of various diseases. In view of this a series of 2-(1-benzofuran-2-yl)-quinoline-4-carboxylic acids and their resultant esters were evaluated for their antitubercular activity against H37Rv strain by Microplate Alamar Blue Assay (MABA) method. In silico cheminformatics studies on bioactivity prediction was carried out using mole information. The results revealed that the analogues 4a, 5b-c and 6a-b exhibited excellent antitubercular potential at concentration of 1.6 μg/ml. The compounds 4b-c and 7c exhibited good activity at 6.25 μg/ml and compounds 5a, 6c, and 7a-b showed significant activity at 12.5 μg/ml when compared with standard drugs pyrazinamide, streptomycin and ciprofloxacin. Benzofuran coupled quinoline moieties are vital for activity as they possess excellent drug-like characteristics, suggesting being potentially best inhibitor of H37Rv strain. The in silico bioactivity study also revealed that the compounds have significant interaction with the drug targets.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 15261

Der Pharma Chemica received 15261 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry