The anti-ulcer activity of methanolic extract of leaves of Hibiscus cannabinus (Malvaceae) MEHC was investigated by Pylorus ligation and Indomethacin (8mg/kg;p.o) induced ulcer models in wistar rats. Ulcer index was used as the common parameter to determine the activity. MEHC at doses of 1.6 & 3.2g/kg p.o produced significant inhibition of the gastric lesions produced by Pylorus ligation & indomethacin. It also significantly (P<0.05) reduces gastric volume, free acidity and ulcer index as compared to control. The data obtained suggests that MEHC possess potent anti-ulcer activity ie.,antiulcerogenic and ulcer healing properties, which might be due to its antisecretory activity. The presence of flavanoids in the extract supports its activity. Hibiscus cannabinus (Malvaceae) commonly known as Mesta is cultivated all over India. In ayurvedic medicine, leaves are used in the treatment of dysentery and bilious, blood and throat disorders. The seed possess pain reducing effect when applied externally. It effectively delayed the onset of cataract formation.