GET THE APP

Application of RP-HPLC for the simultaneous determination of ciprofloxacin hydrochloride and tinidazole in solid dosage form | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Application of RP-HPLC for the simultaneous determination of ciprofloxacin hydrochloride and tinidazole in solid dosage form

Author(s): *Mayank Sharma, Bhupendra Kumar Pandey, S. K. Yadav, Swaraj Patil, Nitin Choudhary and Ganesh Prasad Mishra

A simple, precise, accurate, rapid and reproducible reverse phase high performance liquid chromatographic procedure is developed for simultaneous determination of Ciprofloxacin Hydrochloride and Tinidazole in tablet formulations. The mobile phase used was a combination of acetonitrile: water: triethylamine (30:67:3) v/v and the pH was adjusted to 6.0±0.1 by addition of 50% ortho phosphoric acid. The detection of the tablet dosage form was carried out at 296 nm and a flow rate employed was 1ml/min. Linearity was obtained in the concentration range of 2-16 mg/ml of Ciprofloxacin Hydrochloride and 5 -55 mg/ml of Tinidazole with a correlation coefficient of 0.9992 and 0.9996 respectively. The results of the analysis were validated statistically and recovery studies confirmed the accuracy of the proposed method. The developed method has been successfully used for the simultaneous estimation of both drugs in commercial formulation.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 23677

Der Pharma Chemica received 23677 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry