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Assay of fexofenadine hydrochloride in pharmaceutical preparation by visible spectrophotometry | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Assay of fexofenadine hydrochloride in pharmaceutical preparation by visible spectrophotometry

Author(s): K. Raghubabu and K. Sanadhyarani*

A simple and sensitive visible spectrophotometric method is described for the determination of fexofenadine hydrochloride in bulk and solid dosage forms. This method is based on the reaction of drug with aromatic aldehyde such as Vanillin in the presence of sulphuric acid in non-aqueous medium and formed coloured condensation product with an absorption maximum of 590nm for the Method. The Beers law obeyed in the concentration range of 50-300 μg/ml. The proposed method is validated with respect to accuracy, precision, linearity and limit of detection. The suggested procedure is successfully applied to the determination of the durg in pharmaceutical preparation, with high percentage of recovery, good accuracy and precision. The result of analysis is validated satistically by repeatability and recovery studies. The result is found satisfactory and reproducible. This method is applied successfullyl for the estimation of fexofenadine hydrochloride in tablet dosage form without the interference of excipients.


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