2- Azetidinone is a β- lactam cyclic amide with four atoms in a ring. This nucleus has attracted considerable attention as they are endowed with a wide range of pharmaceutical activities. This β- lactam is part of antibiotics such as penicillin’s, cephalosporins, and carbapenams. These molecules interfere with the final step of bacterial cell wall biosynthesis by inhibition of the D,Dtranspeptidase enzyme involved in the cross linking of peptidoglycon strands, which are also known as penicillin binding proteins. The mechanism based inhibitor prevents the construction of cell wall and eventually lead to cell lysis and death. Cyclization of Schiff bases with chloroacetylchloride in the presence of triethylamine result in the formation of 2-azetidinone. The present work is an attempt to review chemistry, synthesis, and biological activities of 2- azetidinone.
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