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Base Catalysed One Pot Multicomponent Synthesis of Novel 6-(3-Nitrophenyl)-7, 9-Dihydro-1H-Purine-2, 8 (3H,6H)-Dithione via a Three-Component Biginelli Type Condensation Derivatives under Microwave Irradiation | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Base Catalysed One Pot Multicomponent Synthesis of Novel 6-(3-Nitrophenyl)-7, 9-Dihydro-1H-Purine-2, 8 (3H,6H)-Dithione via a Three-Component Biginelli Type Condensation Derivatives under Microwave Irradiation

Author(s): Rahul Jaiswar*

An efficient one-pot synthesis of novel 6-(3-nitrophenyl)-7, 9-dihydro-1H-purine-2,8 (3H,6H)-dithione via a three-component biginelli type condensation of 2-thiohydantoin, aldehyde and urea/thiourea in the presence of fused Sodium acetate and acetic acid as a solvent using microwave irradiation was carried out. The use of microwave irradiation in organic synthesis has become increasingly popular within the pharmaceutical and academic arenas, because it is new enabling technology for drug discovery and development. By taking advantage of his efficient source of energy compound libraries for lead generation and optimization can be assembled in a fraction for time required by classical thermal methods.In the last decades the MW technique has been intensively used to carry out organic reactions of almost all kinds and has become a useful non-conventional means of performing organic syntheses.


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