Plasmodium berghei is transmitted by Anopheles mosquitoes and it infects the liver after being injected into the bloodstream by a bite of an infected female mosquito. We have reported the synthesis of benzothiazole derivatives (compound 3a-b) by condensing 2-aminothiophenol with different aromatic aldehydes in polyethylene glycol-400 and the progress of the reaction was monitored using thin-layer chromatography, with dichloromethane and n-hexane used as a developing solvent in the ratio of 2:1. The synthesized compound was characterized by 13C-Nuclear Magnetic Resonance and 1H- Nuclear Magnetic Resonance. The acute toxicity of the synthesized compound was evaluated and found to be less toxic. The antimalarial activity of the compound was also studied in-vitro using albino mice and the result showed that the compound has significant antimalarial activity against Plasmodium berghei.
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