BF3.Et2O catalyzed synthesis and antioxidant evaluation of benzyl/arylphosphonates | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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BF3.Et2O catalyzed synthesis and antioxidant evaluation of benzyl/arylphosphonates

Author(s): Sk. Nayab Rasool, K. Chandra Sekhar, Natava Rajesh and C.Naga Raju

A series of novel benzyl/arylphosphonates were synthesized by the BF3.Et2O catalyzed Michaelis-Arbuzov reaction where by the reaction of 3-trifluorobenzylbromide/5-bromonicotinic acid with various trialkyl phosphites in the N2 atmosphere. All the synthesized compounds were characterized by their spectral analysis. The title compounds were screened for their anti-oxidant activity DPPH and Superoxide radical scavenging activities. The compounds 3d, 3i and3j were exhibited the good consequences.


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