Three component condendensation of B-keto ester, aldehyde and urea or thiourea catalyzed by layered double hydroxide ( LDH) to give 3,4-dihydropyrimidin-2(1H)-one is described. Catalyst has high region specific and chemo selective activity as well as no toxicity. It is cheap eco-friendly and easily synthesized catalyst. The mild reaction conditions, easy isolation of the product and high yields are the important features of this protocol.
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