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Bioactive halogenosubstituted cinnamic acids: Synthesis by Knoevenagel condensation using conventional as well as microwave irradiation | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Bioactive halogenosubstituted cinnamic acids: Synthesis by Knoevenagel condensation using conventional as well as microwave irradiation

Author(s): Archana Shetye, Majid Tamboli, Shyam Mokle and Sainath Zangade

Halogenosubstituted vanillins were prepared by halogenations. Halogenosubstituted vanillins on Knoevenagel condensation with malonic acid to form halogenosubstituted cinnamic acids by using conventional method as well as microwave irradiation technique. All halogenosubstituted cinnamic acids were screened for antibacterial activity. All newly synthesized halogenosubstituted cinnamic acids showed antibacterial activity to a remarkable extent.


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