Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Biochemical Studies in Cat fish (Clarious lazera) Infected with Flavobacterium columnare and Treated with probiotic
Author(s): Mona S. Zaki, Nabila EL Battrawy and Samy I ShalabyThe present study was planned to investigate the effect of Flavobacterium columnare infection on some hematological, serum biochemical and pathological alterations of Clarious lazera. Forty five fish were divided into three equal groups. Fish of first group served as a control. Fish of group (2&3) were naturally infected by Flavobacterium columnare. Fish of group (3) were treated after 7 days of post-infection using the probiotic bacterium, Lactobacillus rhamonsus for 10 days. Sampling was done after 1 and 7 days of post-infection (gps 1 & 2) and 10 days of post-treatment (gps 1& 3). The results revealed a non significant changes in the hematological and the biochemical parameters after 1 day of infection, but after 7 days of post-infection and 10 days of post-treatment, a significant decrease in RBCs, Hb, PCV and significant increase in AST, ALT, urea, creatinine, sodium, potassium, cortisol, insulin and glucose were seen. Iron showed a significant decrease at the same period of sampling. The infected skin loses its natural sheen and a gray, white or yellowish margin surrounds the foal lesion. The mouth and inner walls of the oral cavity may be covered with a yellowish mucoid material. In scaly- less fishes, the lesions start with simple ulcers which predominately end with extensive saddleback-like ulcers exposing the underlying musculatures. Fin and gill rot is another lesion of the progressive infection in both scaly and scaly-less fishes. These reactions were evident, after 7 days of post-infection and the severity of the lesions were markedly decreased after 10 days of post-treatment. It could be concluded that, Flavobacterium columnare infections induced marked tissue alterations as well as some hematological and serum biochemical changes. Although probiotic treated the infected cases and allowed the regenerative processes but it does not progress the hematological and serum biochemical parameters.
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