Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Biological activities of (E)-N-(CH3-substituted-phenyl)-1-phenylmethanimine: Evaluation of ortho-, meta- and para- substitution effects

Author(s): Victor N. Mkpenie*, Iniobong V. Mkpenie and Emmanuel E. Essien

Schiff bases with ortho-, meta- and para-methyl substituents were synthesized by the condensation of appropriate aromatic amines (o-, m- and p-toluidine) with benzaldehyde. The structures of all the synthesized compounds were confirmed by analytical and spectral data. The sensitivity of the bacteria and fungi was evaluated by measuring the zones of inhibition exhibited by the microorganisms against the tested compounds using disk diffusion method. The results of the antimicrobial activity showed that the methyl group substituted at meta and para positions exhibited more antifungal and antibacterial activities compared to the ortho and unsubstituted derivatives. The results showed that antifungal and antibacterial activities are affected by the position of substituents in the aryl ring of the Schiff bases