Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Biological activity studies on some transition metal complexes containing thiazole moiety. Microwave synthesis, spectral, thermal characterization and computational modeling

Author(s): Rajendra K. Jain, D.K. Mishra and A.P. Mishra

Some new Schiff base metal complexes of Cr(III), Co(II), Ni(II) and Cu(II) derived from 5- bromosalicylidene-2-amino-5-methylthiazole (HL1) and 2-hydroxy-1-naphthylidene-2-amino- 5-nitrothiazole (HL2) have been synthesized by conventional as well as microwave methods. These compounds have been characterized by elemental analysis, FT-IR, FAB-mass, molar conductance, electronic spectra, 1H-NMR, ESR, magnetic susceptibility, thermal, cyclic voltammetry, electrical conductivity and XRD analysis. The complexes exhibit coordination number 4 or 6. The complexes are coloured and stable in air. Analytical data revealed that all the complexes exhibited 1:2 (metal: ligand) ratio. IR data shows that the ligand coordinates with the metal ions in a bidentate manner through the phenolic oxygen and azomethine nitrogen. FAB-mass and thermal data show degradation pattern of the complexes. The thermal behavior of metal complexes shows that the hydrated complexes lose water molecules of hydration in the first step; followed by decomposition of ligand molecules in the subsequent steps. The Schiff base and metal complexes show a good activity against the Gram-positive bacteria; Staphylococcus aureus and Gram-negative bacteria; Escherichia coli and fungi Aspergillus niger and Candida albicans. The antimicrobial results also indicate that the metal complexes are better antimicrobial agents as compared to the Schiff bases.


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