Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Bio-physiochemical characterization of anticancer nano-ceramic polymer scaffold for bone grafting

Author(s): Hanan H. Beherei, Mohamed S. Abdel-Aal, Abdallah A. Shaltout, A. El-Magharby

The main challenge of the implant technology used for bone cancer therapy is the development of a new generation of bioactive implants with enhanced multifunctional roles such as bone graft material and hyperthermia generator. The aim of this work is to prepare nano-ceramic fillersbased hydrogel biopolymer as spongy bone substitute with high biocompatibility, bioactivity, and osteoconductivity. The possibility of preparing a series of nano - brushite/ γ -Fe2O3 / hydrogel biopolymer scaffolds was demonstrated as a new generation of bone graft and tissue engineering. The improvement of bioactivity properties of new scaffolds carried out by adding 5, 10 and 15 wt% of nano - γ - Fe2O3 to 95, 90 and 85 wt% of nano-brushite respectively. The developed nano-ceramic phases were investigated by TEM and XRD. The prepared scaffolds were investigated by pore analysis and mechanical properties before immersion in simulated body fluid (SBF). Due to the applied electromagnetic field the magnetite induces hyperthermia and measuring temperature increases. The in-vitro behavior was assessed via measurement of calcium and phosphorus ions in SBF. The obtained results revealed that the γ - Fe2O3 enhanced the bioactivity properties of the prepared scaffolds by formation of bone-like apatite on surfaces of the scaffolds, especially at high ratio of γ- Fe2O3 (15%) according the measurement of calcium and phosphorous. The mechanical properties of the composites are within the range of cancallous bone. The combination of osteoconductivity properties of these scaffolds confirms excellent mechanical properties which leads to the development of high strength medical scaffolds with appropriate bioactivity and anticancer activity.


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