The aim of this study is to investigate changes in blood biochemical parameters in Ouled Djellal ewes during the peri-partum and dry periods. The study included thirty healthy ewes, blood samples were collected during three periods: one week before parturition, one week after parturition and three weeks after drying off. Results showed that ewes in late pregnancy have the highest blood cholesterol, triglyceride and albumin levels and the lowest glycaemia. Total protein concentration was significantly higher in dry period than on late pregnancy and on early lactation (p< 0,0001) whereas, urea concentration was significantly higher (p< 0,002) on early lactation compared to dry period. On the other hand, calcium levels increase significantly in late pregnancy and decrease significantly in early lactation. However, phosphorus level was significantly higher in dry period and the highest magnesium levels were recorded in late gestation. Current findings regarding blood parameters in late pregnancy, early lactation and dry period may expand the knowledge for interpretation of the metabolic profile in order to establish a diagnosis and a prognosis of reproductive and metabolic diseases in ewes during these periods.