Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Boric acid promoted an efficient and practical synthesis of fused pyrimidines in aqueous media

Author(s): H. M. Meshram, A. Sanjeeva Kumar, G. Santosh Kumar, A. Swetha, B Chennakesava Reddy, P. Ramesh

A very efficient, convenient, mild and practical method is described for the synthesis of fused pyrimidines by three component reaction of β-keto ester, aldehyde and heterocyclic amine in the presence of boric acid in water. The reaction proceeds at rt and yields are high. The method is also amenable for the synthesis of new thiazodihydropyrimidine compounds.


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