Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Characterization of Acyl Homoserine Lactone of pigment producing Pseudomonas aeruginosa SU-3

Author(s): Antony V. Samrot, Syed Azeemullah A, Sujitha R, Suhail Azharudeen M, Sree Samanvitha K and Sahaya Sneha J

Quorum Sensing (QS), a communication process is prevalent among most bacteria. Acyl Homoserine Lactone (AHL) is the most common QS molecule produced by Pseudomonas aeruginosa and Quorum sensing is believed to be responsible for biofilm formation, pigment production and antibiotic resistance in Pseudomonas aeruginosa. In this study, pigment producing and biofilm forming P.aeruginosa was isolated from air. Autoinducer molecule responsible for quorum sensing was extracted and characterised by HPLC and LC-MS analysis. The isolated autoinducer molecule was analysed for its role in pigment (pyocyanin) production and it was found to enhance the pigment production.


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