Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Characterization of antiradical and anti-inflammatory activities of some cold pressed oils in carrageenan-induced rat model of acute inflammation

Author(s): Hanan Naeim Attia, Faten M. Ibrahim, Yousreya A. Maklad, Kawkab A. Ahmed and Mohamed Fawzy Ramadan

Inflammation is a process involving multiple factors acting in a complex network, where a distinct cytokine cascade of pro-inflammatory and inflammatory mediators unfolds. Substantial levels of bioactive phytochemicals were found in cold-pressed oils (CPO). To evaluate the antiradical and anti-inflammatory potential of CPO including Nigella sativa oil (BCO), Coriandrum sativum oil (COO), and Syzygium aromaticum oil (CLO). Indomethacin was used as the reference standard. In vitro assays were undertaken to evaluate radical scavenging properties utilizing stable 1,1-diphenyl-2-picrylhydrazyl (DPPH??) and galvinoxyl radicals. In vivo studies comprised carrageenan (CG)- induced rat paw edema as a model for acute inflammation. Biochemical estimations of tumor necrosis factor-α (TNFα), interleukin 6 (IL-6), and interleukin 12 (IL-12) were evaluated in paw exudates and sera of treated as well as untreated animals groups. Histopathological examination of rat paw sections was carried out. In vitro assays revealed strong radical scavenging potential of CPO against stable DPPH?? and galvinoxyl radicals with CLO showing the highest radical quenching activity. Pro-inflammatory cytokine levels were markedly improved as compared to untreated CG group. CLO exhibited superior attenuation of pro-inflammatory release as compared to BCO, COO, and indomethacin. Rat paw sections of CPO-treated groups showed a marked improvement in histopathological alterations induced by CG injection. Attenuation of inflammatory mediators by bioactive constituents of the selected CPO, together with the antioxidant potential, might represent a possible prophylactic or therapeutic target against inflammation and subsequent free radical generation.


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