GET THE APP

Characterization of HmuY, a unique heme-binding protein of Tannerella forsythia and Porphyromonas gingivalis as a nomination for pharmaceutical treatment of periodontitis | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

ilbet

süperbetin giriş

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

agariookey oyna istanbul okey

Abstract

Characterization of HmuY, a unique heme-binding protein of Tannerella forsythia and Porphyromonas gingivalis as a nomination for pharmaceutical treatment of periodontitis

Author(s): Maryam Pourhajibagher, Nasim Chiniforush and Abbas Bahador

Periodontitis, a chronic polymicrobial disease of the gums, affects the soft tissues and bone that support the teeth. Porphyromonas gingivalis and Tannerella forsythia are the major human bacterial pathogens responsible for periodontitis. They bind to and accumulate on the tooth surface, develop the biofilm matrix and form a periodontal pocket. These pathogenes acquire heme from host hemoproteins using the HmuY hemophore for nutrition and growth. This study will mostly concentrate on the characterization of HmuY as a unique heme acquisition system using of bioinformatic tools to introduce it as a candidate novel drug against periodontal pathogens.There results show that HmuY is a stable protein which is a membrane-associated heme-binding lipoprotein. The unique feature and the crystal structure of heme-bound HmuY reveal the presence of His 134 and His 166 residues. Protein interaction network have displayed that TonB- dependent receptor HmuR is in close relationship with HmuY. In conclusion, we revealed molecular properties of HmuY protein that can be as a putative virulence agent during bacterial infection. These features make it an appropriate candidate for biomedical applications against periodontal pathogens.


PDF

rokettube brazzers

Turkish dental care is known to be affordable compared to other countries. If you want an affordible dentist Turkey, check out periodonta. It is heavily recommended for dental patients visiting Turkey