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Characterization, synthesis and biological evaluation of naphthalene based piperazines as anti bacterial agents | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Characterization, synthesis and biological evaluation of naphthalene based piperazines as anti bacterial agents

Author(s): Ramachandrula Krishna Kumar, Ramanayam S K Sharma, D. Ravi Kumar, Shrikanth. H. Havale, B.Basaveswararao and S.V. Murali Mohan Rao

The present research paper has been focused on synthesis of naphthalene based piperazine molecules by adopting appropriate synthetic steps. Purification of intermediates and final titled compounds has been done by recrystallization and also by chromatographic techniques. Characterization of all the synthesized naphthalene derivatives including intermediates by physical and spectral data like IR, Proton NMR and Mass. Biological evaluation of the newly synthesized compounds for their pharmacological activity has been studied and found that the synthesized compounds were active against Gram positive and Gram negative bacteria like Satphylococcus aureus, Escherichia coli, Bacillus subtilis and Klebsiella pneumonia by adopting standard protocols.


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