Sambucus nigra is a species complex of flowering plants in the family Adoxaceaenative to most of Europe and North America. Common names include elder, elderberry, black elder, European elder, European elderberry and European black elderberry. It grows in a variety of conditions including both wet and dry fertile soils, primarily in sunny locations the aim of this study is to overview its therapeutic effects than its nutritive and industrial effects. This review article was carried out by searching studies in PubMed, Medline, Web of Science, and Iran Medex databases up to 2016.Totally, of 109 found articles, 40 articles were included. The search terms were “elderflower”, “therapeutic”, “pharmacological”. Various studies have shown that elder flower (Sambucus nigra).Antioxidant effect, Photo- protective effect, Bone Mineral Density, Antivirus effect, Anti-allergy effect, Antiurolithiasic effect, Anti-Toxoplasma activities, and Antidiabetic effect .elderflower (Sambucus nigra) is widely used for therapeutic and purposes that trigger its significant value. Various combinations and numerous medicinal properties of its extract, essential oils, its stems and leaves demand further and more studies about the other useful and unknown properties of this multipurpose plant.