Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Chemical constituents and cytotoxicity of the leaves of Dysoxylum gaudichaudianum (A. Juss.) Miq.

Author(s): Consolacion Y. Ragasa, Vincent Antonio S. Ng, Mariquit M. De Los Reyes, Emelina H. Mandia, Glenn G. Oyong, Chien-Chang Shen

The crude dicloromethane leaf extract of Dysoxylum gaudichaudianum (A. Juss.) Miq. was tested for cytotoxicity against breast cancer (MCF-7) and colon cancer (HT-29) cells and exhibited IC50 values of 7.35 and 13.19 μg/mL, respectively. Chemical investigation of the dichloromethane leaf extract afforded squalene (1), β-sitosterol (2), polyprenols (3) and triglyceride (4). The structures of 1-4 were identified by comparison of their 1H NMR data with those reported in the literature. These compounds are known cytotoxic and anticancer compounds.


PDF

FIND ARTICLES
SCImago Journal & Country Rank
Recommended Conferences
bornova escort karşıyaka escort osmangazi escort buca escort anne porno fetiş porno anal porno bartın escort burdur escort eskişehir escort escort izmir bursa escort porno escort bayan