Acalypha fruticosa Forssk. [Family Euphorbiaceae] commonly known as ‘Chinnichedi’ and ‘Birch-leaved Acalypha’ is a strong smelling bushy shrub traditionally used to treat dyspepsia, stomachache, skin diseases, wounds and poisonous bites. In the present study the aerial parts of Acalypha fruticosa were analysed for phytochemicals and minerals. Qualitative analysis of phytochemicals of the various extracts of the aerial parts of Acalypha fruticosa indicated the presence of triterpenoids, steroids, saponins, tannins, phenols, flavonoids, alkaloids, anthraquinones and sugars. Quantitative estimation of phytoconstituents in the powdered samples of Acalypha fruticosa showed that flavonoids were present in high amount when compared to alkaloids, tannins, phenols and steroids. 1, 2- Benzenedicarboxylic acid diisooctyl ester, n-Hexadecanoic acid, 9, 12-octadecadienoic acid [z, z], α-D-glucopyranoside and eicosyltrichlorosilane were identified by Gas Chromatogram-Mass spectrometry [GC-MS] analysis of the extracts. Potassium, sodium, calcium, magnesium, sulphur, zinc, copper, iron, manganese, boron and molybdenum were estimated using atomic absorption spectrophotometer. Phytochemicals and minerals analysed in the present study may account for the medicinal properties of Acalypha fruticosa.