Spectrophotometric methods for the simultaneous determination of Bisoprolol (BIS), Hydrochlorothiazide (HCT) and Ramipril (RAM) in their dosage form were developed. These methods are chemometric based on treatment of data, the applied chemometric techniques are multivariate methods including Classical Least Squares (CLS), Principal Component Regression (PCR) and Partial Least Squares (PLS). In these techniques, the concentration data matrix were prepared by using the synthetic mixtures containing the three drugs dissolved in 0.1 M NaOH. The absorbance data matrix corresponding to the concentration data matrix was obtained by measuring the absorbance in the range 235-245 nm at 1 nm intervals in the zero-order. The spectrophotometric procedures are simple, do not require any separation step. The developed methods were validated by calculating validation diagnositics after analyzing dosage form containing the studied drugs. The developed methods were successfully applied routinly in quality control laboratory.