Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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‘Claycop’ catalyzed highly efficient and chemoselective aza-Michael addition under solvent free condition

Author(s): Rayala Naveen Kumar and H. M. Meshram

A chemoselective and highly efficient addition of amines to electron deficient alkenes is described in the presence of claycop in solvent free condition. The reaction is very rapid and exhibited higher yields in comparison with slurry reaction. Claycop can be readily recovered and reused after activation. This method is suitable for a variety of amines and alkenes. Solvent free condition and recyclability of supported catalyst makes procedure more environmental friendly.


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