Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Comparative study of synthesis of ethyl (quinolin-8-yloxy)acetate by conventional, microwave & ultrasound irradiation techniques

Author(s): Gaurav Desai, Ashish Asrondkar, Vrushali Patil, Anil Bobade and Abhay Chowdhary

Microwave and Ultrasound assisted organic synthesis has emerged as a new “lead” in organic synthesis. The technique offers simple, clean, fast, efficient, and economic for the synthesis of a large number of organic molecules. In the recent year microwave assisted organic reaction has emerged as new tool in organic synthesis. Important advantage of this technology include highly accelerated rate of the reaction, Reduction in reaction time with an improvement in the yield and quality of the product. A series of various ethyl (quinolin-8-yloxy)acetate derivatives were synthesized by the reaction of chloroethylacetate with substituted 8-hydroxy quinoline under conventional, Ultrasound irradiation and microwave irradiation conditions, purified by recrystallisation and the structure of all the compounds have been confirmed by IR, NMR and Mass spectral data.