Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Comparison of lyophilization and compression technique of Risperidone oral disintegrating tablets

Author(s): Venkata Ramana Reddy S, Sathyanarayana Dondeti, Manavalan R, Sreekanth J

The aim of the present investigation was to develop oral disintegrating tablets (ODT) of insoluble and bitter drug like risperidone using taste masking agents, taste enhancers and flavors. ODT of risperidone were prepared using different process like lyophlization and compressed tablets technique. Amberlite was used a taste masking agent, Mannitol was used as a diluent and peppermint was used as a flavoring agent. The formulations were prepared and evaluated for weight variation, hardness, friability, dispersion time, disintegrating time, taste evaluation study and in vitro dissolution. All the formulation showed low weight variation with different disintegration time and rapid in vitro dissolution. The results revealed that the tablets containing taste masking had a good palatability for the patients. The drug content of all the formulations was within the acceptable limits of the United States Pharmacopoeia XXVII. The optimized formulation showed good taste masking, less disintegration time (<30seconds) and release profile with maximum drug being released at all time intervals. It was concluded that risperidone ODT’s with improved taste masking and dissolution could be prepared by both lyophilization and compressed tablet technique with suitable taste masking agent like amberlite. This work helped in understanding the effect of formulation processing variables of lyophilization and compressed tablet technique, especially the disintegrating and taste masking agents on the drug taste masking, disintegration time and release profile. The present study demonstrated potentials for rapid disintegration in oral cavity with out water, improved taste masking and patient compliance.


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