The novel Coronavirus Disease (COVID-19) also known as Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) has transpired as a new pandemic, threatening the world. The finding of a new drug or vaccine would considerably take a long duration of time. Hence the possible drug therapy includes re-purposed already existing drugs against different ailments. There are no guaranteed solutions to ensure the spread of infectious diseases, before they reach densely populated areas. But we need to have cost-effective ways of widening the scope of its cure. This review highlights the various re-modified uses of the already existing xenobiotic for therapy of COVID-19 and explains their plausible mechanism on the new virus.