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Computer aided docking studies of indole derivatives as Hepatitis C NS5B
Author(s): Thayaillany Rajandran, Radha Prabhu and M. Prabhu
Hepatitis C is a liver disease caused by the Hepatitis C virus (HCV) and the infection has affected approximately180 million people around the world. Nonstructural protein 5B (NS5B) polymerase is a viral protein found in HCV and it plays a major role in the replication of the virus. Over the decade, it has been found that inhibition of the enzyme prevents the replication of the virus and thus treats the disease. In this study, molecular docking was performed on a series of 2-phenylindole derivatives by Autodock 4.2 into active sites of NS5B polymerase enzyme.