Crystal and molecular structure studies of cinnarizinium dimaleate | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Crystal and molecular structure studies of cinnarizinium dimaleate

Author(s): C. S. Chidan Kumar, S. Naveen, R. Venkatachalapathy, K. N. Anilraj and S. Chandraju

The title salt {systematic name: 1-diphenylmethyl-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine-1,4-diium bis (hydrogen maleate)}, crystallizes in the monoclinic space group P21, with a = 9.940 (2) Å, b = 27.115 (6) Å, c = 11.802 (3) Å, β = 98.403 (3)°, V = 3146.8 (12) Å and Z = 2. The piperazine ring is protonated at both the N atoms and adopts a distorted chair conformation. The sum of the bond angles around the piperazine N atoms N1 and N2 indicates that they are sp3 hybridized. The structure exhibits both intra- and intermolecular hydrogen bonds of the type O—H•••O and N—H•••O.


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