Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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DABCO: An Efficient and Green Catalyst for One Pot Four-Component Synthesis of 11-Amino-12-(4-Aryl)-8,9,10,12-Tetrahydro-7H-Chromeno[2,3-b]Quinolin-3-ol Derivatives

Author(s): Akash D Gholap, Vishal U Pandit, Abhijeet S Somwanshi, Rushikesh D Ghogare, Shivaji S Pandit

A series of 11-amino-12-(4-aryl)-8,9,10,12-tetrahydro-7H-chromeno[2,3-b]quinolinol derivatives were synthesized through one-pot four-component reaction of resorcinol, malononitrile, aromatic aldehydes and cyclohexanone in presence of DABCO (diazabicyclo[2.2.2]octane) as an inexpensive catalyst under solvent-free condition using stone grinding techniques and at room temperature. The advantages of this method are the use of an inexpensive and green catalyst, short reaction time and easy workup with good to excellent product yields.


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