Datura stramonium is a foul-smelling, erect, annual, freely branching herb plant in the nightshade family, indigenous to Mexico, naturalized in many other parts of the world. While this plant has lots of properties, the aim of this study is to overview its therapeutic effects than its industrial effects. This review article was carried out by searching studies in PubMed, Medline, Web of Science, and IranMedex databases 1990 to 2016.totally, of 87 found articles, 50 articleswere included. The search terms were “Datura stramonium”, “therapeutic”, “pharmacological”, Various studies have shown that Datura stramonium PossessNeurological effects , Anti-obesity ,Antioxidative effects ,Anti-infection ,Anti-viral activity ,Rhizogenic activity Anticholinergic activity ,Immune modulatory effect ,Tropinone-reductase activities ,Enzyme activities ,Lectin properties ,Bronchodilator effects Datura stramonium was shown that is negatively correlated with infection progression. The wealth of scientific literature supports the proposal that Datura stramonium consumption have significant antimicrobial and antiinfection effect, which include both animal and human studies. But certain issues regarding the proper use of garlic, i.e use of different preparations available, dose, duration and interaction with generic drugs should be optimized. Further research should also be carried out to identify specific compounds from Datura stramonium or its products that are responsible for most of its biological effects.