Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Dehydration of 1,2,3-triaryl-3-hydroxy-1-propanones: An alternatve route for synthesis of triaryl-2-propen-1-ones

Author(s): Viwat Hahnvajanawong, Baramee Pungpis and Parinya Theramongkol

N-Heterocyclic carbene-catalyzed reaction of aromatic aldehydes with benzyl halides leads to formation of 1,3- diaryl-3-hydroxy-2-phenylpropan-1-ones. Subsequent dehydration offers a route to 1,3-diaryl-2-phenyl-2-propen-1- ones.


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