GET THE APP

Derivative spectrophotometric methods for determination of aprepitant in bulk and pharmaceutical formulation | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Derivative spectrophotometric methods for determination of aprepitant in bulk and pharmaceutical formulation

Author(s): Benjamin.T, Rajyalakshmi. Ch and Rambabu. C

Simple, fast and reliable derivative spectrophotometric methods were developed for determination of Aprepitant in bulk and pharmaceutical dosage forms. The solutions of standard and the sample were prepared in methanol. The quantitative determination of the drug was carried out using the zero order derivative values measured at 210 nm and the first order derivative values measured at 269 nm (n=6).Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of Aprepitant using 6-14 μg.mL-1 (r² = 0.998and r² = 0.998) for zero order and first order derivative spectrophotometric method. All the proposed methods have been extensively validated as per ICH guidelines. There was no significant difference between the performance of the proposed methods regarding the mean values and standard deviations. Developed spectrophotometric methods in this study are simple, accurate, precise and sensitive to assay of Aprepitant in tablets.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 23677

Der Pharma Chemica received 23677 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry