Poor water solubility and slow dissolution rate are issues for the majority of upcoming and existing biologically active compounds.Zaltoprofen is a novel non–steroidal anti-inflammatory class of drug, but problem associated with is the poor solubility in biological fluids. Zaltoprofen is BCS Class-II having low solubility and high permeability. The purpose of the present investigation was to increase the solubility and dissolution rate of Zaltoprofen by the preparation of nanosuspension by nanoprecipitation technique. Prepared nanosuspension was evaluated for its particle size and in-vitro dissolution study and characterized by differential scanning calorimetry and scanning electron microscopy. The optimized formulation showed an average particle size (237 nm) and zeta potential (-21.5 mV). The rate of dissolution of the optimized nanosuspension was enhanced (89 % in 50 min) relative to micronized suspension of Zaltoprofen (30 % in 50 min), mainly due to the formulation of nanosized particles. Stability study revealed that nanosuspension was more stable at room and refrigerator condition with no significant change in particle size distribution. These results indicate that the Zaltoprofen loaded nanosuspension significantly improved in-vitro dissolution rate and thus possibly enhance fast onset of therapeutic drug effect.
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