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Design and Synthesis of (2-(furanyl)vinyl)-1-tetralone Chalcones as Anticancer Agents | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Design and Synthesis of (2-(furanyl)vinyl)-1-tetralone Chalcones as Anticancer Agents

Author(s): Sarah K Zingales, Morgan E Moore

Ten chalcones (1a-e and 2a-e) were synthesized by the Claisen-Schmidt reaction. These compounds were submitted to PASS online for determination of likely biological activities and further QSAR analysis. These chalcones were predicted to have anticancer activity, specifically as inducers of apoptosis.


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