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Design and synthesis of hydrazone incorporated pyrazoles and triazoles as possible antioxidants | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Design and synthesis of hydrazone incorporated pyrazoles and triazoles as possible antioxidants

Author(s): Shobhitha Shetty and Balakrishna Kalluraya

Novel series of hydrazone incorporated pyrazoles and 1,2,3-triazole were synthesized and evaluated for their antioxidant activity by DPPH scavenging assay. Title compounds were prepared from 5-methyl-1-(p-nitro phenyl)- 1H-1,2,3-triazole-4-carbohydrazide (3) by reaction with appropriate pyrazole aldehydes. Among the tested compounds, compound 11a, 12d and 12e exhibited good scavenging activity.


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