Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Design and synthesis of N-substituted aminothiazole compounds as anti-inflammatory agents

Author(s): Aneesa Fatima, Ravindra Kulkarni and Bhagavanraju Mantipragada

A series of new N-(4-phenyl-1, 3-thiazol-2-yl) benzamides (5a-o) has been synthesized from 2-amino-4-substituted phenylthiazoles and substituted benzoyl chlorides. The structures of synthesized compounds were established based on spectral (FT IR, 1H NMR, ESI Mass) analysis. The final fifteen compounds were screened for anti-inflammatory activity by following carrageenan induced rat paw edema method. Among the compounds screened, N-(4-phenyl-1, 3-thiazol-2-yl) 4-chlorobenzamide (5c) and N-[4-(3-chlorophenyl)-1, 3-thiazol-2-yl]-3-trifluro methylbenzamide (5n) were found to be more potent.


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