A series of imidazole derivatives (4 a-e) have been synthesized from 2-(4-chlorophenyl)-4, 5-diphenyl-1H-imidazole- 1-yl)-acetic acid hydrazide under various reaction conditions. Elemental analysis, IR, 1H NMR and mass spectral data confirmed the structure of the newly synthesized compounds. All the synthesized imidazole derivatives have been investigated for their anti-inflammatory, anti-bacterial and antifungal effect and showed moderate to good activity.
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