GET THE APP

Design and synthesis of some new imidazole and 1,2,4-triazole substituted fluorobenzimidazoles for antitubercular and antifungal activity | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Design and synthesis of some new imidazole and 1,2,4-triazole substituted fluorobenzimidazoles for antitubercular and antifungal activity

Author(s): B. Nandha*, L. V. G. Nargund and S. L. Nargund

A series of thirteen imidazole and 1,2,4-triazole substituted fluoro benzimidazoles (8a-i), (9a-b) and (11a-b) with phenyl and benzyl group at 2nd position were synthesized and screened for antitubercular activity against H37RV strain and antifungal activity against Candida species. Both imidazole and 1,2,4-triazole substituted fluoro benzimidazoles with 2-benzyl and 4-N(CH3)2 substituted 2-phenyl/2-phenyl-1-benzyl counterpart were found to be the most active of all the compounds. To examine the influence of azole moiety on the activity chlorine substituted fluoro benzimidazole (5) was synthesized. The newly synthesized compounds were characterized by I.R, 1H-NMR, 13C-NMR, Mass and elemental analysis. In vitro antitubercular and antifungal activity data revealed that the benzimidazole scaffold with imidazole or triazole moiety were important for antitubercular and antifungal activity.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 25868

Der Pharma Chemica received 25868 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry