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Design and synthesis of some novel 6-methoxynaphthalene derivatives with Potential anticancer activity | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Design and synthesis of some novel 6-methoxynaphthalene derivatives with Potential anticancer activity

Author(s): Maha M A Khalifa , Magda M F Ismail, Sally I Eisa and Yousry Ammar

Starting from the naphthalene derivative, which belongs to the arylpropanoic acid family of NSAIDs, certain 6- methoxynaphthalene derivatives have been synthesized, and evaluated for their antiproliferative activities. The preliminary assays indicated that compounds 6b-d, 16 were found to have promising inhibitory activity against Colon cancer cell line HCT-116. Molecular modeling and docking of the active compounds into AKR1C3 complexed with its bound inhibitor Indomethacin using Molsoft ICM 3.4-8C program was performed in order to predict the affinity and orientation of the synthesized compounds at the active site. Detailed synthesis, spectroscopic and biological data are reported.


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