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Design, synthesis and antibacterial activity of novel 1, 3-thiazolidine purine nucleosides | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Design, synthesis and antibacterial activity of novel 1, 3-thiazolidine purine nucleosides

Author(s): B. K. Manuprasad, V. Srinivasa Murthy, S. Shashikanth, D. Rakshith, S. Satish, K. A. Raveeshab

We have described a facile synthesis of novel 1,3-thiazolidine purine nucleosides. All these analogues are derived from the key intermediate N-tert-butoxycarbonyl-1,3-thiazolidine-2-ol, which was obtained from L-cysteine methylester hydrochloride. The tetrabutylammonium fluoride (TBAF) induced coupling of the 1,3-thiazolidine moiety with suitably protected purines afforded highly regioselective N-9 substituted purine nucleosides. All the newly synthesized products were characterized by 1H NMR, ES-MS and elemental analyses. Their antibacterial activity is reported.


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