Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Design, Synthesis and Anticancer Screening of Novel Benzothienopyarno Fused System: A Step in Discovering a Promising Anticancer Motif
Author(s): Ashraf F Zahera, Afaf El-Malaha, Zeinab MahmoudaThe diversity and prevalence of cancer disease is a chocking fact. Accordingly, the need for new, effective and safe anticancer agents is now mandatory. Fourteen novel tricyclic and tetracyclic benzothienopyrano and benzothienopyranopyrimidine derivatives 2, 3a-d, 4a-c, 5-8 and 9a,b were synthesized. Compounds 3b and 3d have been chosen by the NCI-USA for the 60-cell lines One-Dose screening and Five-dose assay. Both 3b and 3d exhibited very potent cytotoxic effects (GI50 ï?£ 2.0 ïM) against almost all cell lines. 3b showed TGI values ranging from 0.463–4.75 ïM while 3d showed values of 0.571–6.28 ïM. The best sensitivity patterns for both 3b and 3d were against MDA-MB-435 subpanel (melanoma cancer) while they possessed a null sensitivity towards all leukemic cancer subpanels.
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Citations : 25868
Der Pharma Chemica received 25868 citations as per Google Scholar report
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